Weight-loss compound may help shed fat without eating less

A compound called TOFA helped obese mice lose 18% of their body weight without eating less, while preserving lean tissue and improving blood sugar and liver fat.Medicines such as semaglutide and tirzepatide have changed how doctors treat obesity and type 2 diabetes. They copy signals from gut hormones, including GLP-1, that reduce hunger. These drugs can help people lose weight, but they can also cause nausea and other digestive problems. Some people may lose lean tissue, including muscle, which could create health problems over time. Obesity often appears with high blood sugar and excess liver fat. Researchers at the University...