HIV Can Convert T Cells From Helpers to Killers

Some CD4 T cells infected with HIV can take on the characteristics of CD8 cells, according to a study published in Science. The researchers found that this transformed population of induced CD8 cells can still harbor latent HIV and contributes to the viral reservoir, which has implications for functional cure strategies. Antiretroviral therapy can keep HIV suppressed indefinitely, but the virus inserts its genetic blueprints into host cells and establishes a long-lasting viral reservoir that is impervious to the drugs and usually invisible to the immune system, making a true cure nearly impossible.