With Spidey returning to the big screen in Spider-Man: Brand New Day, Marvel's favorite Wall-Crawler goes up against his toughest threat yet. But in the pages of Marvel Comics — at least, his most mainstream comics — it's not uncommon for the Web-Slinger to go up against opponents much more powerful than himself. When it comes to the most powerful characters in Spider-Man comics, there are probably even more than we could list here, but don't sleep on these impressive threats.
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